Kefir Grains usually have little or no trouble adjusting to different types of milk from same mammal. For example Cow’s milk: Full Cream, low fat and 2% or brand to brand (all being Cows milk) You may see that the consistency may be thicker or thinner than usual but the grains will not need help to adjust, it will normalize by itself. If you switch from Cows milk to Goats’ then there might be a longer adjustment period – a week or so. NB: Goats’ milk and yogurt is thinner in consistency than Cows Milk the same is applicable to kefir. You can also expect to see your Grains change in form when switching from one milk to the next.